If you didn’t get a chance to tune into this weeks interview, be sure to download this pod cast!
I had the distinct pleasure to interview Dr. Pamela Stanley!!
Education.
Dr. Stanley received her Ph.D. in department of microbiology, University of Melbourne, Australia. She then served as a postdoctoral fellow of the Medical Research Council of Canadian the Department of Medical Genetics, University of Toronto, Canada. Dr. Stanley now runs a lab at The Albert Einstein College of Medicine.
Research Initiatives.
Dr. Stanley’s Laboratory is actively working to further understand post translational modifications of proteins, with understanding that they are critical in determining biological functions. Dr. Stanley’s lab points out that by understanding the precise complement of glycans and their composition on cell surface glycoproteins they can further understand the changes present in embryonic development , inflammatory responses, and transformation of cancer cells.
Dr. Stanley’s lab in collaboration with others has pointed out the specificity and importance of the notch receptor and its ability to control signal transduction by Notch Ligands. With this they have found that the presence of a single sugar residue alerts the ability of notch receptors to signal. By using Knockout mice, CHO cell mutants and MALDI-TOF mass spec, they are able to further delve into this discovery in order to map and understand the role that sugars play in mediation and modulation of Notch Signaling. How is it that certain proteins secreted from cancer cells can actually help cancers Progress?
A few questions you will have answered by listening to this interview!
How did Dr. Stanley get into this field of research?
What are the specific roles of the Notch receptor and what is the History of its discovery?
How is it possible for Drosophila and Humans to have a specific sugar that relates to the Notch receptor in both organisms?
What can be expected in the future of the field?
And finally one for Dr. Stanley: Why do I Pronounce Glycomics the way I do?
These are just a few of the questions we posed in the interview with Dr. Stanley. The intricacy of her research and the prolific role her lab lays within the field is certainly too vast to squeeze into a half hour. However it is well worth it, and I am sure you will find the interview as I did….. Incredibly interesting, Fun and light hearted, and leaving you wishing for a few hours……
Here is the link to Dr. Stanley’s web page and labs.
http://stanxterm.aecom.yu.edu/
Department of cell biology: Albert Einstein College OF Medicine.
http://www.aecom.yu.edu/cellbiology/
http://www.aecom.yu.edu/home/default.asp
http://www.aecom.yu.edu/cellbiology/stanley.htm
Check out Dr. Stanley’s List of Publications.
